Cork tree bark, particularly from the Phellodendron amurense (Amur cork tree), has a long history of medicinal use in traditional Chinese medicine. It’s used to address various ailments, including inflammation, gastroenteritis, abdominal pain, and diarrhea. Active compounds like berberine, palmatine, and phellodendrine are believed to contribute to its therapeutic effects.

1. Anti-inflammatory Properties:
Phellodendron amurense bark extract, often marketed as Nexrutine, is known for its anti-inflammatory effects.
It is believed to inhibit the production of inflammatory molecules like COX-2 and TNF-alpha.
This makes it potentially useful for conditions like arthritis and other inflammatory disorders.
2. Anti-cancer Potential:
Studies suggest that the bark extract can inhibit the growth of certain cancer cells, including prostate and lung cancer cells.
It may work by modulating Akt and CREB signaling pathways, which are involved in cell growth and survival.
Nexrutine has shown promise in preventing the progression of aggressive prostate cancer, with some studies suggesting it’s as effective as exercise.
3. Digestive Health:
It has been traditionally used to treat digestive issues like gastroenteritis and diarrhea.
The anti-inflammatory properties likely play a role in soothing the digestive tract.
4. Other Potential Uses: Lowering blood pressure, Treating urinary tract infections, Reducing cholesterol and blood sugar levels, and Managing skin conditions.